READYCELL SL

24 or 96 transwell insert plates seeded with 21 days differentiated and polarized Caco-2 cells. This cell model is considered to be the gold standard for assessing intestinal permeability of new oral drugs in in vitro preclinical studies, according to leading regulatory agencies.

24 or 96 transwell insert plates cultured with 12 days differentiated MDR1-overexpressing MDCKII cells. The MDR1 efflux transporter has an ubiquitous tissue distribution, with a critical role in intestinal absorption, biliary and urinary excretion of drugs and in the entry of active molecules into the central nervous system.

24 or 96 transwell insert plates cultured with 12 days differentiated BCRP-overexpressing MDCKII cells. BCRP is a high-capacity efflux transporter with broad substrate specificity. It is located in the apical cell membrane of barrier tissues and and excretory organs.

24 transwell insert plates seeded with 21 days differentiated and polarized Caco-2 and HT-29 cells with an absorptive and mucus-secreting phenotype, respectively. This co-culture allows evaluating the in vitro intestinal absorption of drug targets at a barrier physiologically closer to the intestinal epithelium. In addition, their responsiveness to inflammatory mediators provides valuable information on the efficacy of anti-inflammatory drugs.